Global Journal of Pure and Applied Chemistry Research (GJPACR)

EA Journals


Extraction, Isolation and Characterization of Mannitol from aerial part of Striga hermonthica Del (Published)

Striga hermonthica (Del.) Benth is a common hemi-parasitic plant growing in a variety of food crops like maize, millet, rice and sorghum roots.  It has many medicinal uses include abortifacient, dermatosis, leprosy, ulcer, pneumonia, jaundice and antibacterial activities. The plant material was extracted and concentrated under reduced pressure. Bioassay guided isolation was done by chromatographic methods. Compound coded “003” was isolated as white amorphous substance from combined hexane and ethyl acetate extracts. Spectral analysis was carried out to characterize the isolated compound. The proton Nuclear Magnetic Resonance (1H-NMR) spectrum of isolated compound 003 displayed seven chemical shifts; δ H 4.31ppm, δ H 3.38 ppm, δ H 3.61 ppm, δ H 4.39 ppm, δ H 3.46 ppm, δ H 4.12 ppm and δ H 3.55 ppm. This also showed that there are seven different types of protons in the compound. Interpretation of the spectrum also revealed that signal of alcoholic protons of OH were observed downfield compared with the signal of protons directly attached to carbons. The Carbon-13 Nuclear Magnetic Resonance (13C-NMR) spectrum gave three peak signals at δ C 64.3, 71.9 and 70.3 ppm corresponding to C1/C6, C2/C5 and C3/C4 respectively. Based on the comparison of the spectra of the isolated compound with reported spectral data in the literature, the chemical structure of the isolated compound 003 was deduced and identified as Mannitol. The chemical structure was also confirmed by 1H-1H Correlation Spectroscopy (COSY), Hetero-nuclear single quantum correlation (HSQC) and Hetero-nuclear Multiple Bond Correlation (HMBC) spectra.

Keywords: Characterization, Extraction, Isolation, mannitol, striga hermonthica

Preparation, Characterization and Study the Biological Activity of New No2, Novel N2o2 Ligands and Their Complexes with [Co (Ii), Cu (Ii), Ni (Ii), Mn (Ii) and Hg (Ii)] Ions (Published)

A new two Schiff bases derivatives was synthesized and characterized with studying their biological activity and employed anganese (II),Cobalt (II),Nickel(II),Copper(II) and Mercury (II) complexes: 2 – ((Z) – 4 – ((Z)-2-hydroxy-1, 2-diphenylethylideneamino)-1, 5 – dimethyl – 2-phenyl-1H-pyrazol-3(2H)-ylideneamino) benzoicacid and (E)-4-(2-hydroxy-1, 2-diphenylethylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one. The first ligand were obtained through a reaction of Benzoin and 4-Aminoantipyrine while the second result from the condensation of the first ligand with 2-amino benzoic acid. Ten new coordination compounds were synthesized and structurally characterized: [Co(L1)(Cl)], [Cu(L1)(Cl)] [Ni(L1)(Cl)],[Mn(L1)(Cl)],[Hg(L1)(Cl)],[Co(L2)],[Ni(L2)],[Cu(L2)], [Mn(L2)] and [Hg (L2)]. All of the suggested chemical structures of the prepared ligands and metal complexes are confirmed by using FT- IR, UV, 1H& 13C-NMR spectra. Most of the prepared compounds show antibacterial activity to (Staphylococcus aureus), (Escherichia coli), (Bacillus subtilis) and (Pseudomonas aeroginosa).

Keywords: 2-Aminobenzoicacid, 4-Amino Antipyrine, Benzoin, Biological Activity, Characterization, Schiff Bases

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