Biochemical Evaluation of Harungana Madagascariensis Lam Aqueous Leaf Extract in Diabetic Rats (Published)
Effects of aqueous leaf extract of Harungana madagascariensis Lam. ex Poir (Family: Hypericacea) on alloxan-induced diabetic rats were investigated. 500 mg/kg body weight extract was administered orally twice daily for 7 days. Blood glucose, cholesterol, bilirubin, alanine aminotransferase (ALT) and alkaline phosphatase (AP) levels hitherto raised in diabetic rats consequent upon induction of diabetes, were significantly (p<0.05) reduced following administration of the extract, except for ALT (p>0.05) . In contrast, the significant (p<0.05) decrease in plasma protein of the rats injected with alloxan were significantly (p<0.05) increased by administration of the extract compared to diabetic control rats, suggesting membrane structure and integrity of liver cells were restored. Neither alloxan nor the extract had any significant effect on albumin concentration. The results indicate the aqueous extract of Harungana madagascariensis leaf is antihyperglycaemic and antihypercholesterolaemic justifying its folkloric use as a diabetic agent and appears to have the propensity to restore damaged liver cells back to functionality.
This study was carried out to investigate the effect of Zinc supplementation on the serum levels of TT4 and TT3 . Zinc concentration was determined by atomic absorption spectroscopy in sera of diabetic patients’ type (2) and healthy individuals. The results show a high significant deficiency of zinc concentration (P < 0.001) in diabetic patients when comparison with healthy group. In addition ,our study investigates the effect of zinc oral supplementation on thyroids hormones in diabetics (Type 2) by the use of two control groups ( A:Healthy control ) , and ( B : Diabetic control ) , and C-group treated with zinc supplements for 10 weeks period .The results shows that the elevation of TT4 and TT3 level in C group after the intake of zinc supplementation and this elevation was highly significant (P< 0.001) .