Infrastructural constraints in Nigeria militate against efficient performance of Small and Medium Scale Enterprises (SMEs) and adversely affect industrial growth in the country. The objective of the study was to determine the relationship that exists between manufacturing SMEs production and industrial growth in Nigeria. Secondary data were sourced from the Central Bank of Nigeria statistical bulletin and National Bureau of Statistics publications for the period 2002-2016, and regression analysis was used in analysing the data. Findings of the study revealed that manufacturing SMEs production has a statistical significant relationship with industrial growth in Nigeria. This implies that manufacturing SMEs are capable of accelerating industrial growth through their contributions to the economy. The study, however, advocates more government intervention of facilitating access to concessional funds to SMEs to trigger SMEs sustainable growth and industrial growth in Nigeria.