Antimalarial, Antibacterial, and Phytochemical Contribution of Prosopis Africana Stem Bark Methanolic Extract (Published)
The Prosopis africana (Fabaceae) plant is traditionally used in the treatment of Hepatic disease, malaria, new wounds and fever . Phytochemical screening, antibacterial and In vitro antiplasmodial activities of Prosopis africana stem bark methanolic extract was investigated against S. epidermidis, M. smegmatis, E. faecalis, S. aureus, B. subtilis) and Gram-negative strains K. aerugninosa, P. vulgaris, K. pneumonia, K. oxytoca, E. cloacae, P. asaccharolyticus, E. coli, P. mirabilis. Minimum Inhibitory Concentration (MIC) and the Minimum Bactericidal Concentration (MBC) of the extract showed activities against S. epidermidis, M. smegmatis, S. aureus, B. aureus,) and Gram-negative strains P. mirabilis, K. oxytoca, E. cloacae, P. asaccharolyticus, E. coli). The extract has broad spectrum against bacteria. The LD50 value was greater than 5000mg/kg body weight. It also has a high potent for antiplasmodial activities with P. bargie inhibition of 76.52%. The phytochemical screening and GC-MS profiling indicated the present of secondary metabolites that may be responsible for the antimalarial and antibacterial activities of the extract. The results explicitly indicated that Prosopis africana stem bark methanolic extract can be used as a source of cheaper, less toxic antimalarial and antibiotic agent for drug development.