The objective of this research work is to evaluation of cellular immunity for β-thalassemia major patients in Wasit Thalassemia center. Methods: hematological parameters including (Hb, WBCs), Phagocytic activity by Nitroblue Tetrazolium stain (NBT) and Enzyme linked Immuno Sorbent Assay (ELIZA) applied for estimation of the serum cytokines included IL-8, TNF-α and IFN-γ from 60 male β-thalassemia major patients and twenty healthy persons as control group. Results: the hematological parameters including Hb concentration shows significant decrease but WBCs count appeared significant increased compared with control group and significant decreased in the neutrophil activity. Interleukin-8, TNF-α and IFN-γ concentration showed significant decreased compared with control group. Conclusions: significant increase in the WBCs count and significant decrease in the Hb concentration, neutrophil activity and Interleukin-8, TNF-α and IFN-γ concentration compared with control group.
Keywords: Immunity, Infection, thalassemia
