Hydrothermal Synthesis and Characterization of Copper Glycinate and Its In Vitro Drugs Adsorption Studies (Published)

A new porous compound, Copper Glycinate (Bio-MOF-29), [Cu (C2H4NO2)2 (H2O)] has been synthesized by the hydrothermal method and characterized by single crystal XRD analysis. Bio-MOF-29 crystallized in orthorhombic crystal system with P212121 space group. In vitro adsorption studies of four different drugs, terazosin hydrochloride, telmisartan, glimpiride and rosu-vastatin have been carried out for Bio-MOF-29. Drugs adsorption estimations of drugs loaded Bio-MOF-29 have been carried out through High Performance Liquid Chromatography (HPLC), which reveals that these drugs are successfully adsorbed in it. Also the slow release of adsorbed drugs after intervals was observed through HPLC. Thermograms and powder XRD patterns of Bio-MOF-29 before and after drugs adsorption were also recorded to elaborate the phenomenon of drugs adsorption in Bio-MOF-29.

Keywords: : Bio-Metal Organic Framework, Glimpiride, Glycine, High Performance Liquid Chromatography, Single Crystal XRD Analysis, Telmisartan, Terazosine HCl

Preparation and Characterization of Some New Complexes of Schiff Bases Derived From Benzoin and Glycine (Published)

A new series of complexes containing benzoin and glycine compounds were prepared as ligands, ligand was prepared by the reacting between benzoin and glycine to give the corresponding Schiff base compound ((E)-2-((2-hydroxy-1,2-diphenylethylidene) amino) propanoic acid). The complexes M(HDPENP)2 – of Cu(II), Ni(II), Co(II), Zn(II) and Fe(II) contaning Schiff base compound has been synthesized by the reacting between copper bromide, hydrate nickel chloride, hydrate cobalt chloride, zinc chloride, and iron bromide and Schiff base in 1:2 mole ratio. It has been isolated in the solid state and characterized by (C.H.N) data, IR and 1H NMR spectroscopy. Six coordinate and octahedral complexes were producted and the results are reported and discussed below

Keywords: Benzoin, Complexes, Glycine, Metal Complexes, Schiff Base