This research investigated the influence of job stress and organisational justice on burnout among academic staff of polytechnics in South West Nigeria. The research adopted descriptive survey research method and multi stage sampling technique. The population for this research is the entire staff of polytechnics in South West Nigeria and the participants consists of four hundred and eighty (480) academic staff of polytechnics in South West Nigeria who were selected through multi-stage random sampling technique. Three major instruments were adopted to collect data for this study. Namely: Job-Related Tension Index (JRTI) developed by Kahn, Wolfe, Quinn, Snock and Rosenthal (1964), Measure of Organisational Justice (MOJ) developed by Colquit (2001) and Maslach Burnout Inventory (MBI) developed by Maslach and Jackson (1986). Findings of this research revealed significant influence of job stress and organisational justice on burnout among the participants. It also revealed no significant gender difference in burnout among academic staff of polytechnics in South West Nigeria. While contributing to the existing knowledge on the research area, it also made recommendations to management, regulatory bodies and government at large on policies and strategies that can be put in place in polytechnics to reduce or eradicate burnout
Keywords: Academic Staff, Burnout, Job Stress, Nigeria, Organisational Justice, Polytechnics, South-west