IRON CHELATORS FOR LABILE IRON REMOVAL THERAPY AND ENHANCEMENT OF LONGEVITY (Published)
Abnormally high levels of non-transferrin-bound iron ions (NTBI), or labile iron ion, have been demonstrated in a number of neurodegenerative disorders including dementia, Parkinson’s disease (PD) and Alzheimer’s disease (AD), and oxidative stress due to NTBI is believed to be associated with neuronal death in these diseases. We have prepared the new iron chelators, so-called super-polyphenols, in order to delete these dangerous NTBI. Our super-polyphenols are characterized by the following four points, i.e., 1) the super-polyphenols are water-insoluble, but can catch iron(III) ion in the aqueous solution with ease, 2) their iron (III) chelates are also water-insoluble, 3) these are not metabolized in the human body due to its insolubility in water and its polymeric structure (MW~90,000), and 4) they do not interact with the iron ions in the transferrin. Since our super-polyphenols can excrete only NTBI effectively from the plasma and give no damage to human body, our super-polyphenols may be one of the most important substances for labile iron removal therapy, including the prevention of dementia, Alzheimer’s and Parkinson’s diseases, and also for the enhancement of longevity
Keywords: Hydrogen medicine, Longevity, NTBI, Super-polyphenols