IRON CHELATORS FOR LABILE IRON REMOVAL THERAPY AND ENHANCEMENT OF LONGEVITY (Published)
Abnormally high levels of non-transferrin-bound iron ions (NTBI), or labile iron ion, have been demonstrated in a number of neurodegenerative disorders including dementia, Parkinson’s disease (PD) and Alzheimer’s disease (AD), and oxidative stress due to NTBI is believed to be associated with neuronal death in these diseases. We have prepared the new iron chelators, so-called super-polyphenols, in order to delete these dangerous NTBI. Our super-polyphenols are characterized by the following four points, i.e., 1) the super-polyphenols are water-insoluble, but can catch iron(III) ion in the aqueous solution with ease, 2) their iron (III) chelates are also water-insoluble, 3) these are not metabolized in the human body due to its insolubility in water and its polymeric structure (MW~90,000), and 4) they do not interact with the iron ions in the transferrin. Since our super-polyphenols can excrete only NTBI effectively from the plasma and give no damage to human body, our super-polyphenols may be one of the most important substances for labile iron removal therapy, including the prevention of dementia, Alzheimer’s and Parkinson’s diseases, and also for the enhancement of longevity
Keywords: Hydrogen medicine, Longevity, NTBI, Super-polyphenols
DIET AND LIFESTYLE: A PANACEA FOR ACHIEVING LONGEVITY IN UGEP, NIGERIA (Published)
The body cannot be healthier than the food man eats. Nutrition is to health what drug is to the body too. This paper seeks to highlight the relationship between diet and longevity most importantly in prevention of morbidity and recovery from ill-health. Nutrition is coming to the fore as a major modifiable determinant of chronic disease, with scientific evidence increasingly supporting the view that alterations in diet have strong effects, both positive and negative, on health throughout life. Diet has been known for many years to play a key role as a risk factor for chronic disease. Hunger, malnutrition and poor lifestyle remain among the most devastating problems facing the majority of the world’s poor and needy people; our communities inclusive. The Objective is to clarify the role of diet in preventing and controlling morbidity and premature mortality resulting from non-communicable diseases (NCDs). Using Health Belief Model (HBM), questionnaire was designed for data collection, 100 questionnaires were administered, interviews and existing literature were used too. Data generated were analyzed using descriptive statistics such as mean, simple percentages and illustrative graphs. The findings show that poverty, ignorance, poor lifestyle and inequality were discovered to be the major limiting factors to proper nutrition which would have boosted health and longevity. The study demonstrated 65% increase in morbidity cases among the low income earners and the ignorant as to the average income earners and the ignorant. The result shows that there is a strong relationship between nutrition and health. Ignorance, as one of the limiting factors to proper dieting, is at the fore front. Base on this study/ findings, it is recommended that local food be patronized too in our locality and stakeholders should organize food/agricultural programmes at least annually to ensure knowledge is increased on proper nutrition with the aim of promoting healthy living
Keywords: Lifestyle, Local Food, Longevity, Panacea