Concern for hyperglycemia due to diabetes mellitus and its complications in male diabetics prompted the need for this study. Making use of body fluids such as urine, seminal fluid, serum sample and excised tissues, we examined factors that can potentiate complications. Batteries of tests conducted includes insulin, glucose, glycated haemoglobin, urea, creatinine and some male sex hormones, FSH, LH and testosterone. Spectrophotometric, radioimmunoassay and histopathological approach were adopted for the analytical methods. A total of 100 subjects were studied out of which 50 were non diabetics as defined by their glucose concentration (3.5-5.6 mmol) and 50 diabetics with glucose concentration ranging from (15.5-35.5 mmol/l). Our findings portray a correlation among the factors and elicit a nexus that interrelate to cause complication in diabetes. Values of the analyte measured after a 24 hour fast showed a significant difference (p<0.05) between the diabetics and non diabetics while no statistical significant difference was observed among the normal subjects. We submit that variation in the values of biochemical parameters measured and their interactive interplay act in uncommon way to exercerbate diabetic complications and reduce fertility in males. Inhibiting these factors highlighted from rising will improve fertility among male diabetics.