Background: Remote ischemic pre- conditioning (RIPC) is a technique where the application of short, repetitive limb intervals of ischemia and reperfusion would result in the condition of the heart as well as other organs to tolerate the ischemic reperfusion injury.
Methods: Many research groups are interested in investigating the mediators, through which this technique works. Many mediators have been suggested to mediate the protective actions of RIPC.Conclusion: This manuscript represents a short review explaining a possible mechanism of action of this technique, through recent published findings, which confirm the ability of the technique to play an important role in the clinical practice of heart transplantation.
Keywords: And Heart Transplantation, Inflammasomes, Inflammatory Cytokines, Ischemic Preconditioning, Nitric Oxide, Remote Ischemic Preconditioning
