Study to Toxoplasma, Rubella, CMV, Chlamydia and Herpes of women with recurrent spontaneous abortion in Babylon Province (Published)
Background: The acute and chronic infections which are caused by Toxoplasma gondii, Rubella virus, Cytomegalovirus (CMV) and the Herpes Simplex Virus (HSV ) during pregnancy are often associated with adverse foetal outcomes and reproductive failures. Objective: This study aims at evaluating IgM, IgG antibodies for acute and chronic infection for more causes of abortion spreading that is Toxoplasma, Rubella, CMV, Chlamydia and Herpes Methods.Methods and Materials: Sera were collected from the women with Bon and they were tested for the presence of specific IgM, IgG antibodies against the Toxoplasma gondii, Rubella virus, Cytomegalovirus (CMV) and the Herpes Simplex Virus (HSV ) infections by ELISA. The specific IgM antibodies were found to be positive :Result toxoplasmosis, in 126 (30.4%) cases for the Rubella virus, in 130 (34.7%) cases for CMV and in 151 samples (33.5%) for the HSV-2 infections.Alsospecific IgG antibodies were found to be positive in 74(19.4%) cases for toxoplasmosis, in 126 (30.4%) cases for the Rubella virus, in 130 (34.7%) cases for CMV and in 151samples (33.5%) for the HSV infections .Conclusion: The present study demonstrates a strong association between the infectious agents (Toxoplasma gondii, Rubella virus, Cytomegalovirus (CMV) and the Herpes Simplex Virus (HSV )) and abortion inwomen. It is thereforrecommended that all antenatal cases with such historyshould be routinely screened for these agents (IgM and IgG).
Keywords: Pregnant Women, Specific IgG ELISA, Specific IgM ELISA, TORCH infection