Global Journal of Pure and Applied Chemistry Research (GJPACR)

EA Journals

Synthesis of New Higher Homologues of Quisqualic Acid

Abstract

The compounds such as methyl 2-(tert-butoxycarbonyl)-4-(3,5-dioxo-4-phenyl-1,2,4-oxadiazolidin-2-yl)butanoate and 2-amino-4-(3,5-dioxo-4-phenyl-1,2,4-oxadiazolidin-2-yl)butanoic acid, higher homologues of quisqualic acid, have been synthesized in a first time via N-alkylation reaction of 4-phenyl-1,2,4-oxadiazolidine-3,5-dione by alkyl 2-(tert-butoxycarbonyl)-4-iodobutanoate in presence of potassium carbonate as base in dry acetone. The structures of the synthesized compounds were established by 1H-NMR, MS data and elemental analysis.

Keywords: Quisqualic Acid; N-alkylation Reaction; Glutamate Receptor

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Email ID: submission@ea-journals.org
Impact Factor: 7.76
Print ISSN: 2055-0073
Online ISSN: 2055-0081
DOI: https://doi.org/10.37745/gjpacr.2013

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