Evaluation of the Pharmacological Activities of Beta-Sitosterol Isolated From the Bark of Sarcocephalus Latifolius (Smith Bruce) (Published)
Beta Sitosterol was previously isolated from the bark of Sarcocephalus latifolius (smith Bruce). This was subjected to antimicrobial screening with the following microorganisms to determine its pharmacological activities; Methycilin Resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Streptococcus pyrogenes, Bacillus subtilis, Corynebacterium ulcerans, Escherichia coli, proteus mirabilis, proteus vulgaris, Pseudomonas aureginosa, Salmonella typhi, Shigellia dysenteric, Candida albicans, Candida virusei, and Candida tropicalis. The zone of inhibition was observed to be between 20 to 27 mm with Bacillus subtilis and Salmonella typhi to be the most sensitive organism with the highest zones of inhibition of 27mm. The Beta Sitosterol was found to inhibit Staphylococcus aureus, Streptococcus pyrogenes, Bacillus subtilis, Corynebacterium ulcerans, vulgaris, Pseudomonas aureginosa, Salmonella typhi, Shigellia dysenteric, Candida albicans and Candida virusei at 12.5µg/ml. While the MBC/MFC was minimum for Bacillus subtilis ,Salmonella typhi and Shigellia dysenteric at 25µg/ml, and Staphylococcus aureus, Streptococcus pyrogene, Corynebacterium ulcerans, Proteus vulgaris, Proteus aureginosa, Candida albicans and Candida virusei were at 50µg/ml. The result further shows that it could be compared with a standard drug.
Keywords: : Pharmacological, Anti-Cancer, Beta-Sitosterol, Microorganism, Sarcocephalus
Evaluation of the Pharmacological Activities of Beta-Sitosterol Isolated From the Bark of Sarcocephalus Latifolius (Smith Bruce) (Published)
Beta Sitosterol was previously isolated from the bark of Sarcocephalus latifolius (smith Bruce). This was subjected to antimicrobial screening with the following microorganisms to determine its pharmacological activities; Methycilin Resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Streptococcus pyrogenes, Bacillus subtilis, Corynebacterium ulcerans, Escherichia coli, proteus mirabilis, proteus vulgaris, Pseudomonas aureginosa, Salmonella typhi, Shigellia dysenteric, Candida albicans, Candida virusei, and Candida tropicalis. The zone of inhibition was observed to be between 20 to 27 mm with Bacillus subtilis and Salmonella typhi to be the most sensitive organism with the highest zones of inhibition of 27mm. The Beta Sitosterol was found to inhibit Staphylococcus aureus, Streptococcus pyrogenes, Bacillus subtilis, Corynebacterium ulcerans, vulgaris, Pseudomonas aureginosa, Salmonella typhi, Shigellia dysenteric, Candida albicans and Candida virusei at 12.5µg/ml. While the MBC/MFC was minimum for Bacillus subtilis ,Salmonella typhi and Shigellia dysenteric at 25µg/ml, and Staphylococcus aureus, Streptococcus pyrogene, Corynebacterium ulcerans, Proteus vulgaris, Proteus aureginosa, Candida albicans and Candida virusei were at 50µg/ml. The result further shows that it could be compared with a standard drug.
Keywords: : Pharmacological, Anti-Cancer, Beta-Sitosterol, Microorganism, Sarcocephalus
Some Pharmacological Activities Of Hexadec-12-Enoic Acid Isolated From Chenopodium Ambrosioides Linn (Published)
The extractive (labelled Sc), from Chenopodium ambrosioides (Linn), which had been characterised as hexadec-12-enoic acid in an earlier work, was tested for analgesic, antipyretic and anti-inflammatory activities. The result for the acetic acid induced writhing test for Sc revealed very high activity, 96.77%, being significantly higher than that of the standard, aspirin i.e. acetyl salicylic acid, (64.68 %). The hot plate analgesic test showed that the activity was not significant and was short-lived compared to that of morphine. The test for antipyretic activity revealed that it possessed not only antipyretic but also hypothermic activity 3 hours after administration. The anti-inflammatory activity of hexadec-12-enoic acid may be involved prostaglandin synthesis inhibition.
Keywords: : Pharmacological, Analgesic, Anti-inflammatory and Antipyretic