Gongronema latifolium (Utazi), a tropical plant native to Nigeria, is traditionally used for both culinary and medicinal purposes. This study examined the effects of its ethanolic root extract on plasma protein, albumin, and globulin levels in Wistar rats. Twelve rats (140–160 g, both sexes) were randomly divided into control and test groups (n=6 each). The control group received standard feed, while the test group received 200 mg/kg body weight of the extract orally for 21 days, alongside standard feed. All animals had free access to water. Blood samples collected post-treatment were analyzed for total plasma protein and albumin using Biuret and Bromocresol green methods, respectively. Globulin was calculated by subtracting albumin from total protein. Results showed a significant increase (P<0.01) in total plasma protein and globulin in the test group, with no change in albumin levels. These findings suggest that G. latifolium root extract may elevate certain plasma proteins without affecting albumin.
Keywords: Ethanolic extract, Gongronema latifolium, Wistar rats., albumin, globulin, plasma protein
