CYTOARCHITECTURAL DISTORTION OF THE LIVER FOLLOWING THE ADMINISTRATION OF AQUEOUS MORINGA OLEIFERA SEED ON ACETAMINOPHEN INDUCED HEPATOTOXICITY IN WISTAR RATS (Published)
This study aimed at elucidating the effects of moringa oleifera seed on acetaminophen (paracetamol) induced hepatotoxicity in wistar rats. Thirty two adult wistar rats were distributed into four treatment groups of eight animals each. Group A received normal chow and distil water, group B received 600mg/kg of moringa oleifera, group C received 6g/kg of paracetamol, group d received 600mg/kg of moringa oleifera and 6g/kg of acetaminophen for ten days. Twenty four hours after the last administration, the experimental animals were sacrificed, the liver was removed and fixed in 10% formal saline. After complete fixation, the tissues were processed and stained with haematoxylin and eosin. Under the light microscope, the histological examination of the liver showed marked tissue changes characterised by marke mononuclear cell infiltration, peripheral fibrosis, scattered limiting plate and dilated sinusoidal spaces in group D. this finding showed that moringa oleifera seed though containing natural antioxidant did not confer hepatoprotective effects on the liver architecture.
Keywords: Liver, cytoarchitectural distortion, moringa oleifera seed, wistar rat