Many facts are demonstrating that the protective effect of the hydrogen molecule against the nephrotoxicity induced by cis-platin should be attributed to that H2 molecule decomposes the peroxide adduct of the iron(III) species, which has been demonstrated to be highly electrophilic, and proposed to be an intrinsic active species to induce nephrotoxicity induced by the several iron(III) chelates, and that labile iron removal therapy by the use of our super-polyphenols should be very useful to depress the side-effects induced by cis-platin. .
Keywords: Cis-Platin, Hydrogen medicine, Labile Iron Removal Therapy., Nephrotoxicity
