Correlation of Serum Lipid Profile with Serum Iron, Tibc & Ferritin Levels in Beta Thalassemia Major Patients (Published)
Correlation of serum lipid profile with serum iron, TIBC & ferritin levels in beta thalassemia major patients. Background- Beta thalassemia major, a common disorder, causes severe anemia. This is treated by regular blood transfusion, leading to iron overload and increased serum ferritin. There is considerable variation between studies as to the serum lipid levels in these patients. Aims- The study was carried out to observe the alteration of serum lipid levels and also whether the alteration could be correlated with ferritin and other hematological indices. Methods and materials-The study was carried out on 50 beta thalassemia major patients and 47 controls. Estimation of serum lipid profile, iron, ferritin, TIBC (Total iron binding capacity), hemoglobin and hematocrit was done. Statistical analysis-Data analysis was performed using standard methods. Results-Compared to controls, the cases had significantly higher ferritin and significantly lower HDL-C (high density lipoprotein- cholesterol) levels. There was inverse correlation between high ferritin and low HDL-C levels. Conclusion-Taken together, high ferritin and low HDL-C levels might be important predictors for mortality in thalassemia.
Keywords: Iron, Lipid profile, TIBC, ferritin, thalassemia
Study the Effect of Probiotic Consumption on the Iraqi Human Body Weight and Lipid Profile (Published)
The effect of probiotic strains on the human were studied. Sixty healthy volunteers were participation in this study , which are divided in three groups, G1 treated with 3 probiotic strains with diet , G2 treated with 2 probiotic strains with diet and G3 (control group) with diet and exercise. The effect of probiotic strains on the body weight showed significantly differences between treated groups .The G1 were decreased the body weight by 8.05% (85 kg to 78.15) and G2 decreased the body weight by 6.4% (82.75 to 77.45) compared with G3 which decrease by 6.63% (87.2 to 81.41). The statistical study showed positive effect of treated by probiotic stains on the W.C. The G1 was decreased it by 7.36% while G2 was decrease it by 7.46%, compared G3 that showed decreasing by 5.16% . The effect of probiotic strains on the lipid profile in human showed that the cholesterol concentrations decreased by 14.41% (149.35)gm/dl vs (170.2)mg/dl after six weeks in the G1 , compared to the G2 9.28% (158.35) mg/dl vs (174.55)mg/d ,in the contrast with G3 was elevated from (167.20) mg/dl vs (174.50) mg/dl. The mean concentration of triglyceride was decreased in the G1 by 28.1% (74.05 mg/dl ) to(53.2)mg/dl and in the G2 was decrease by 17.73% (70.30)mg/dl to(57.85)mg/dl , contrast with G3 was decreased by 14.05% (69.38)mg/dl to (59.63) mg/dl the HDL was elevated in G1 by 8.77%. and in G2 by 4.25 %.comperd with G3 .The LDL was decreased in G1 BY 22% (95.64) to (74.18) mg/dl and by 17.2% (102.61) to (84.92) mg/dl G2 after 6 week intervention compared to the control group (98.93) to( 81.93) mg/dl). This study was showed the significant effect of probiotic strains in different parameters.
Keywords: (BMI) body mass index, Lipid profile, Probiotics
THYROID METABOLIC HORMONES AND ITS CORRELATION WITH BMI AND LIPID PROFILE IN HEALTHY PEOPLE (Published)
Background: Thyroid hormone play an important role in basal lipid metabolism.It is well known that alteration in thyroid function can result in changes in the composition and in the transport of lipoprotein.This study aimed to study the effects of thyroid hormone on serum lipids and evaluted the correlation between thyroid hormone with Body Mass Index (BMI) and lipid profile of healthy people. Methods: Total of 56 healthy people(28 male:28 female) ,aged 30-60 years included in this study.About 5ml of fasting blood (8-12 h.) was collected from each individual.To determine serum Thyroid stimulating hormone (TSH), Triiodothyronine (T3) and Thyroxine (T4) and the quantitative sandwich enzyme immunoassay technique were used.Lipid profile were measured by an enzymatic colorimetric(GPO-POD) method. Results:The result of the present study showed that the levels of triglyceride was significantly higher (p< 0.05) in males than females ,while the levels of triiodothyronine was significantly higher(p< 0.05) in females than males of healthy people.Correlation analysis in healthy males showed positive correlation among BMI with lipid profile,while an inverse correlation between TSH and T4,also an inverse correlation between T3 and HDL .In healthy females there was positive correlation among T3 with BMI and WC,also between T4 and LDL ,while an inverse correlation between TSH and VLDL. Conclusions: Thyroid metabolic hormone especially T3 regulate the resting metabolic rate and the mild thyroid dysfunction was linked to significantly changes in body weight ,lipid profile and likely represents risk factor for healthy and obesity
Keywords: BMI, Healthy people, Lipid profile, Thyroid metabolic hormone
Thyroid Metabolic Hormones and its Correlation with BMI and Lipid Profile in Healthy People (Review Completed - Accepted)
Background:Thyroid hormone play an important role in basal lipid metabolism.It is well known that alteration in thyroid function can result in changes in the composition and in the transport of lipoprotein.This study aimed to study the effects of thyroid hormone on serum lipids and evaluted the correlation between thyroid hormone with Body Mass Index(BMI) and lipid profile of healthy people.
Methods:Total of 56 healthy people(28 male:28 female) ,aged 30-60 years included in this study.About 5ml of fasting blood (8-12 h.) was collected from each individual.To determine serum Thyroid stimulating hormone (TSH), Triiodothyronine (T3) and Thyroxine (T4) and the quantitative sandwich enzyme immunoassay technique were used.Lipid profile were measured by an enzymatic colorimetric(GPO-POD) method.
Results:The result of the present study showed that the levels of triglyceride was significantly higher (p< 0.05) in males than females ,while the levels of triiodothyronine was significantly higher(p< 0.05) in females than males of healthy people.Correlation analysis in healthy males showed positive correlation among BMI with lipid profile,while an inverse correlation between TSH and T4,also an inverse correlation between T3 and HDL .In healthy females there was positive correlation among T3 with BMI and WC,also between T4 and LDL ,while an inverse correlation between TSH and VLDL.
Conclusions:Thyroid metabolic hormone especially T3 regulate the resting metabolic rate and the mild thyroid dysfunction was linked to significantly changes in body weight ,lipid profile and likely represents risk factor for healthy and obesity.
Keywords: BMI, Healthy people, Lipid profile, Thyroid metabolic hormone