Iron injections are frequently utilized to treat anemia in patients undergoing dialysis, given the essential function of iron in the production of red blood cells. [1] Nonetheless, administering excessive or improperly managed iron injections can result in complications, especially in dialysis patients who face existing metabolic and inflammatory issues. [2] This research examines the effect of iron injections on iron storage levels (ferritin) in dialysis patients at hospitals in Jordan. A total of 94 individuals, ranging from 20 to 80 years old, were examined between April 2025 and July 2025. The standard tests include assessing creatinine and hemoglobin levels, as well as measuring ferritin levels using hematology analyzers for hemoglobin and ELISA instruments for ferritin levels. Each 2ml ampoule of CosmoFer contains the equivalent of 100mg of iron in the form of an iron (III)-hydroxide complex, alongside 626mg of water for injection, administered as a bolus injection for 2 minutes for patients undergoing kidney dialysis. To determine the appropriateness of administering monthly iron injections to dialysis patients without prior checks of their blood ferritin levels, I separated the patients into two distinct groups after obtaining their informed consent and clarifying that this study aimed to benefit them. The first group did not receive iron injections, and their ferritin levels were evaluated, revealing normal results. The second group was administered monthly iron injections despite elevated ferritin levels according to hospital protocols. Ferritin levels were measured in both groups, and the group receiving monthly iron showed a notable increase in ferritin levels, with a statistically significant p-value (P-value is ‹‹0.001) indicating this difference. The research found that administering higher amounts of iron and reducing EPO for dialysis patients can decrease the likelihood of EPO-related side effects. Conversely, iron overload is a condition characterized by excessive total body iron content, which may carry a time-sensitive risk of organ dysfunction. Pathological iron overload refers to an elevated body iron content linked with indications of organ dysfunction that are likely due to excess iron. Elevated ferritin levels were correlated with increased mortality rates.
Keywords: Iron Infusion, and creatinine assessments associated with dialysis patients., ferritin levels, hemoglobin
